Comparison · GHRH analog

CJC-1295 No-DAC vs Sermorelin

These compounds share a catalog class. That grouping makes their declared properties useful to compare, but does not establish experimental or clinical interchangeability.

For in vitro and laboratory research only. Not for human or veterinary use, diagnosis or treatment. These research materials have not been evaluated by COFEPRIS.

What distinguishes these compounds

Both entries concern the 1-29 region of GHRH, but CJC-1295 No-DAC is a tetrasubstituted analogue and sermorelin is the amidated human fragment. The declared sequences expose the substitutions directly; neither entry includes the DAC albumin affinity complex.

The No-DAC entry requires particular care when reading CJC-1295 literature: a study of the DAC variant does not establish the same exposure profile for No-DAC. Shared receptor signaling also does not make the two declared sequences interchangeable.

What they are

CJC-1295 No-DAC: CJC-1295 No-DAC is a tetrasubstituted analog of the 1-29 fragment of growth hormone-releasing hormone, without the albumin affinity complex. In preclinical models, it binds to the GHRH receptor and acts as an agonist of that pathway in the anterior pituitary. It has been investigated in models of somatotropic axis signaling in rodent studies.

Sermorelin: Sermorelin is the amidated 1-29 fragment of human growth hormone-releasing hormone. In research models, it binds to the GHRH receptor and acts as an agonist of that pathway in the anterior pituitary. It has been investigated in models of somatotropic axis signaling in rodent studies.

Mechanisms described in the literature

CJC-1295 No-DAC: Substitutions at positions 2, 8, 15 and 27 reduce enzymatic degradation of the sequence in in vitro studies. Activation of the GHRH receptor increases cyclic AMP in cellular models.

Sermorelin: The 1-29 fragment retains the minimal region described for binding to the GHRH receptor. Receptor activation increases cyclic AMP in cellular models.

Declared chemical identity, field by field

A dash means that the catalog does not declare that field for the compound. If neither entry declares a field, the row is omitted. A label purity specification of ≥ 99 % is not an analytical result; results must come from the certificate for the relevant batch.

CJC-1295 No-DAC vs Sermorelin: declared technical information
Field	CJC-1295 No-DAC	Sermorelin
Chemical name	[D-Ala2, Gln8, Ala15, Leu27]-GHRH(1-29) amide	Human GHRH(1-29) amide
Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2	Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Molecular formula	—	C149H246N44O42S
Molecular weight	—	3357.9 Da
CAS number	863288-34-0	86168-78-7
Form	Lyophilized powder	Lyophilized powder
Appearance	White to off-white solid	White to off-white solid
Solubility	Soluble in sterile water and bacteriostatic water	Soluble in sterile water and bacteriostatic water
Storage	−20 °C, protected from light	−20 °C, protected from light
Stability after reconstitution	Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol	Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol

Laboratory handling: CJC-1295 No-DAC

Reconstitution: Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.

Storage: Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.

Protective equipment: Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Laboratory handling: Sermorelin

Protective equipment: Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Literature limitations: CJC-1295 No-DAC

The bibliography brings together work on the analog with DAC and analytical studies that distinguish the two variants. PMID 34665524 includes CJC-1295 without DAC in in vitro research; it does not establish its exposure in humans. Findings for the variant with DAC do not carry over to this preparation.

Catalog presentations

Consult each product page for its current presentations, availability, batch documentation and price. This comparison does not freeze commercial information in the research text.

Complete research references

The compendium entries contain the extended definitions, research context and indexed bibliography for each compound. The comparison organizes declared information; it does not replace study-specific interpretation or batch identity evidence.