Signaling protein; endocrine factor

FGF-19

FGF-19 is an FGF-family signaling protein. In vitro hepatocyte and reconstructed-receptor studies investigate CYP7A1 expression; this molecular evidence does not establish organism-wide metabolic changes.

This is a research reference, not a product offered in the Asciende catalog. Published studies do not establish the identity, purity or availability of a commercial preparation.

Protein, preparation and functional assay

Preserve the particular preparation and assay. Declared mass does not substitute for measured activity, and a protein name does not resolve all its forms.

Which isoform, chain length and preparation were investigated?
Are identity and, where relevant, an activity determination documented?
Does the response arise from the isolated compound or a combination and its vehicle?

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Mechanism described in the literature

In primary human hepatocytes in vitro, FGF-19 reduced CYP7A1 expression and experiments implicated FGFR4–ERK. Other cellular systems showed beta-Klotho- and receptor-subtype-dependent differences between FGF-19 and FGF-21. A shared coreceptor does not make them equivalent.

Other names in the literature

FGF19
Fibroblast growth factor 19

Enzyme expression and total production differ

The human hepatocyte study examined messenger RNA, phosphorylation and signaling-component interventions. Results supported a relationship among FGF-19, FGFR4 and CYP7A1 regulation. An enzyme transcript informs mechanism but does not quantify an organism's entire bile acid pool (PMID 19085950).

Shared binding does not guarantee shared signaling

The 2007 comparison found that both FGF-19 and FGF-21 could associate with beta-Klotho–FGFR4, but FGF-19 signaled more efficiently through it in the studied in vitro systems. Recognition and response must remain distinct; interaction with a common component does not establish identical profiles (PMID 17623664).

Mouse FGF15 is not another name for human material

The literature distinguishes mouse FGF15 and its human ortholog FGF19. Evolutionary relationship supports comparison, not chemical-identity synonymy. Cultured human hepatocytes, mouse models and modified proteins also answer different system-level questions.

Questions and answers

Should FGF15 and FGF19 be recorded as one ingredient?

No. Preserve the names and species of the material used.

Does lower CYP7A1 RNA measure all bile metabolism?

No. It is a specific molecular readout within the cited cellular models.