Somatostatin peptide analog
Octreotide
Octreotide is a somatostatin peptide analog developed as SMS 201-995. Research examines hormone secretion and receptor signaling and trafficking, questions at different experimental levels.
This is a research reference, not a product offered in the Asciende catalog. Published studies do not establish the identity, purity or availability of a commercial preparation.
What changed from the reference
Write the evaluated material’s complete name. A shared family organizes a search but does not establish identity or result equivalence.
- Which modification distinguishes the analog: sequence, terminus, conjugate or formulation?
- Does the study compare both entities using the same assay?
- Do the data separate molecular behavior from presentation effects?
Mechanism described in the literature
In cellular models, octreotide showed activity mainly associated with the sst2 somatostatin receptor. Trafficking experiments also examined relationships among receptor, beta-arrestin and intracellular compartments.
Other names in the literature
- Octreotide
- SMS 201-995
What initial development sought
The 1982 article described successive modifications of a somatostatin analog. It compared secretory activity, degradation resistance and response duration in different experimental systems. Animal models showed differences between GH and other hormone responses. This selectivity concerns those comparisons, not universal absence of activity elsewhere.
Binding is not the end of the receptor story
A 2009 investigation compared octreotide and pasireotide in cells expressing human somatostatin receptors. Compounds differed in internalization and beta-arrestin association in vitro. A binding measurement alone cannot explain later receptor location or changing availability.
Selectivity depends on the variable
Affinity, signaling and trafficking are not interchangeable. Ligands sharing a target can differ in other readouts. Preserve receptor subtype, cell system and measured variable. A finding on sst2 internalization is not a general classification of all somatostatin analogs.
Questions and answers
Does SMS 201-995 identify octreotide?
Yes. It is the code used in the cited original development work.
Do affinity and receptor trafficking describe the same thing?
No. Affinity concerns binding; trafficking examines receptor movement and destination after interaction.
Sources
- SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. — Life Sci, 1982
- SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action.
- Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro. — J Clin Endocrinol Metab, 2009
- Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro.