Neurohypophyseal peptide hormone
Vasopressin
This entry describes arginine vasopressin, an endogenous peptide hormone. Its research connects receptor recognition with tissue-specific responses. The name must be distinguished from lysine vasopressin and modified analogues such as desmopressin or terlipressin.
This is a research reference, not a product offered in the Asciende catalog. Published studies do not establish the identity, purity or availability of a commercial preparation.
Receptor, selectivity and context
Record the receptor panel actually measured. Absence of a result for another receptor does not establish absence of activity.
- Which receptor subtype and species were evaluated?
- Was affinity, functional potency or an integrated response measured?
- Does the comparison include the alternative receptors needed for a selectivity claim?
Mechanism described in the literature
In rat collecting ducts perfused in vitro, vasopressin caused a reversible redistribution of water channels to the apical membrane, accompanied by increased water permeability. The experiment connected cellular localization with function rather than measuring only total channel abundance.
Other names in the literature
- Arginine vasopressin
- AVP
- Argipressin
Where the channel is matters
The 1995 renal study examined permeability and AQP-CD channel distribution in the same tubules. Both changed together during vasopressin exposure in vitro and reversed after withdrawal. This time-course comparison supports redistribution without requiring every rapid response to be explained by new protein synthesis.
A ligand can recognize related receptors
A 2013 study characterized experimentally expressed mouse oxytocin, V1a and V1b receptors. In vitro binding and signaling assays compared vasopressin, oxytocin and analogues. Natural-ligand selectivity was consistent with earlier human and rat findings, but such conservation does not make the receptors identical.
Complementary experimental scales
A collecting duct retains tissue organization that an expressed receptor in a cell line cannot fully reproduce. Controlled expression, in turn, helps separate receptor subtypes. Reading both types of study together addresses ligand recognition and accompanying cellular reorganization without attributing all findings to the same system.
Questions and answers
Is vasopressin another name for desmopressin?
No. Desmopressin is a modified analogue, not the arginine vasopressin hormone described here.
Does more channel at the membrane mean more total protein?
Not necessarily. The renal study examined redistribution between compartments, which differs from measuring total protein abundance.
Sources
- Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. — Proc Natl Acad Sci U S A, 1995
- Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.
- Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors. — J Pharmacol Exp Ther, 2013
- Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors.