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Melanocortins

PT-141

PT-141 is also known as bremelanotide. An alias helps with search, but receiving records should retain the record’s identity, selected presentation and material batch.

ASCIENDE / PT141-1010 mg
10 mg1 unit

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Available · SKU PT141-10

$1,290MXN
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Wholesale quantitiesUp to 50 % off by volume

Sizes of the same compound count together toward volume pricing in your cart. Only the highest eligible discount applies. See volume pricing

For laboratory research only. Not for human or veterinary use.

Delivery in MexicoFree from $2,500 MXN. Shipping terms

Shipping protectionReport damage with photos within 24 hours of delivery for one replacement. Conditions

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About this compound

MC4R is a Gs protein-coupled receptor expressed in hypothalamic nuclei. Its activation modulates cyclic AMP production in cellular models.

Read the complete research reference
Batch documentation

Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.

Review documentation information

Research context & mechanism

MC4R is a Gs protein-coupled receptor expressed in hypothalamic nuclei. Its activation modulates cyclic AMP production in cellular models.

Technical specifications

Reference specifications describe the material. They do not replace the analytical results for a specific batch.

Chemical name
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular formula
C50H68N14O10
Molecular weight
1025.16 Da
CAS number
189691-06-3
Form
Lyophilized powder
Appearance
White to off-white solid
Purity specification
Declared in the batch certificate
Identity
Declared in the batch certificate
Solubility
Soluble in sterile water and bacteriostatic water
Storage
−20 °C, protected from light
Stability after reconstitution
Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol

Batch documentation

Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.

Consult batch certificates How to read documentation

Laboratory handling

Reconstitution
Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
Storage
Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
Protective equipment
Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Research references

  1. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials.

    Obstet Gynecol · 2019 · PMID 31599840

  2. Safety Profile of Bremelanotide Across the Clinical Development Program.

    J Womens Health (Larchmt) · 2022 · PMID 35147466

  3. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist.

    J Sex Med · 2006 · PMID 16839319

  4. Structural insights into ligand recognition and activation of the melanocortin-4 receptor

    Cell Res · 2021 · PMID 34433901

  5. Bremelanotide: an overview of preclinical CNS effects on female sexual function

    J Sex Med · 2007 · PMID 17958619

  6. The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women

    CNS Spectr · 2022 · PMID 33455598

  7. Ultra-sensitive quantification of the therapeutic cyclic peptide bremelanotide utilizing UHPLC-MS/MS for evaluation of its oral plasma pharmacokinetics.

    J Pharm Biomed Anal · 2020 · PMID 32353679

  8. PT-141: a melanocortin agonist for the treatment of sexual dysfunction.

    Ann N Y Acad Sci · 2003 · PMID 12851303

Frequently asked questions

How is PT-141 supplied?

PT-141 is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.

How is PT-141 stored in the laboratory?

Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.

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