Comparison · GHRH analog
CJC-1295 DAC vs Tesamorelin
These compounds share a catalog class. That grouping makes their declared properties useful to compare, but does not establish experimental or clinical interchangeability.
For in vitro and laboratory research only. Not for human or veterinary use, diagnosis or treatment. These research materials have not been evaluated by COFEPRIS.
What distinguishes these compounds
CJC-1295 DAC is based on GHRH(1-29) and includes an albumin affinity complex. Tesamorelin is based on the 44-amino-acid hormone and carries an N-terminal trans-3-hexenoyl modification. Their modifications and underlying lengths differ.
Both entries describe the GHRH receptor and cyclic AMP signaling. That shared pathway does not establish identical degradation, exposure or experimental response. The declared formula and molecular weight for tesamorelin cannot be used to fill missing CJC-1295 DAC fields.
What they are
CJC-1295 DAC: CJC-1295 DAC is an analog of the 1-29 fragment of growth hormone-releasing hormone, with an attached maleimide-type albumin affinity complex. In research literature, it binds to the GHRH receptor and acts as an agonist of that pathway. It has been studied in models of prolonged exposure of the somatotropic axis in preclinical research.
Tesamorelin: Tesamorelin is a stabilized analog of the 44-amino-acid human growth hormone-releasing hormone, modified with a trans-3-hexenoyl group at the N-terminus. In research models, it binds to the GHRH receptor in the anterior pituitary and acts on that signaling pathway. It has been studied in models of the somatotropic axis and adipose tissue distribution in preclinical research.
Mechanisms described in the literature
CJC-1295 DAC: The affinity group forms a covalent bond with serum albumin in in vitro studies, modifying the peptide's exposure profile. The molecular target remains the GHRH receptor, which is coupled to Gs protein.
Tesamorelin: The GHRH receptor is a Gs protein-coupled receptor whose activation increases intracellular cyclic AMP in cellular models. The N-terminal modification reduces enzymatic degradation in in vitro studies.
Declared chemical identity, field by field
A dash means that the catalog does not declare that field for the compound. If neither entry declares a field, the row is omitted. A label purity specification of ≥ 99 % is not an analytical result; results must come from the certificate for the relevant batch.
| Field | CJC-1295 DAC | Tesamorelin |
|---|---|---|
| Chemical name | GHRH(1-29) analog with an albumin affinity complex (DAC) | Trans-3-hexenoyl-GHRH(1-44) amide |
| Molecular formula | — | C221H366N72O67S |
| Molecular weight | — | 5135.9 Da |
| CAS number | 446262-90-4 | 218949-48-5 |
| Form | Lyophilized powder | Lyophilized powder |
| Appearance | White to off-white solid | White to off-white solid |
| Solubility | Soluble in sterile water and bacteriostatic water | Soluble in sterile water and bacteriostatic water |
| Storage | −20 °C, protected from light | −20 °C, protected from light |
| Stability after reconstitution | Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol | Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol |
Laboratory handling: CJC-1295 DAC
Reconstitution: Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
Storage: Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
Protective equipment: Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Laboratory handling: Tesamorelin
Reconstitution: Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
Storage: Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
Protective equipment: Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Catalog presentations
Consult each product page for its current presentations, availability, batch documentation and price. This comparison does not freeze commercial information in the research text.
Complete research references
The compendium entries contain the extended definitions, research context and indexed bibliography for each compound. The comparison organizes declared information; it does not replace study-specific interpretation or batch identity evidence.
Sources
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. — J Clin Endocrinol Metab (2006); PMID 16352683; DOI 10.1210/jc.2005-1536
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. — J Clin Endocrinol Metab (2006); PMID 16352683; DOI 10.1210/jc.2005-1536
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. — J Clin Endocrinol Metab (2006); PMID 17018654; DOI 10.1210/jc.2006-1702
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. — J Clin Endocrinol Metab (2006); PMID 17018654; DOI 10.1210/jc.2006-1702
- Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. — Growth Horm IGF Res (2009); PMID 19386527; DOI 10.1016/j.ghir.2009.03.001
- Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. — Growth Horm IGF Res (2009); PMID 19386527; DOI 10.1016/j.ghir.2009.03.001
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. — Endocrinology (2005); PMID 15817669; DOI 10.1210/en.2004-1286
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. — Endocrinology (2005); PMID 15817669; DOI 10.1210/en.2004-1286
- Metabolic effects of a growth hormone-releasing factor in patients with HIV. — N Engl J Med (2007); PMID 18057338; DOI 10.1056/NEJMoa072375
- Metabolic effects of a growth hormone-releasing factor in patients with HIV. — N Engl J Med (2007); PMID 18057338; DOI 10.1056/NEJMoa072375
- Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. — JAMA (2014); PMID 25038357; DOI 10.1001/jama.2014.8334
- Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. — JAMA (2014); PMID 25038357; DOI 10.1001/jama.2014.8334
- Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial. — Lancet HIV (2019); PMID 31611038; DOI 10.1016/S2352-3018(19)30338-8
- Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial. — Lancet HIV (2019); PMID 31611038; DOI 10.1016/S2352-3018(19)30338-8
- Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials. — Obes Res Clin Pract (2026); PMID 41545261; DOI 10.1016/j.orcp.2026.01.002
- Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials. — Obes Res Clin Pract (2026); PMID 41545261; DOI 10.1016/j.orcp.2026.01.002
- Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects. — Clin Pharmacokinet (2015); PMID 25358450; DOI 10.1007/s40262-014-0202-x
- Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects. — Clin Pharmacokinet (2015); PMID 25358450; DOI 10.1007/s40262-014-0202-x
- Advances in the detection of growth hormone releasing hormone synthetic analogs — Drug Test Anal (2021); PMID 34665524; DOI 10.1002/dta.3183
- PubMed research record — PMID 218949