Cellular compounds and copper complexes
FOXO4-DRI
The DRI suffix is part of FOXO4-DRI and distinguishes its peptide construction. Preserve the complete designation when consulting literature and checking identity; FOXO4 as a protein or target does not by itself identify this material.
Your selected presentation
Availability to be confirmed · SKU FOXO-05
For laboratory research only. Not for human or veterinary use.
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About this compound
According to structural literature, FOXO4-DRI binds to the TAD2 region of p53; both the FOXO4-derived region and the cell-penetrating segment participate in the interaction. These findings describe the experimental construct.
Read the complete research referenceBatch documentation
Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.
Review documentation informationResearch context & mechanism
According to structural literature, FOXO4-DRI binds to the TAD2 region of p53; both the FOXO4-derived region and the cell-penetrating segment participate in the interaction. These findings describe the experimental construct.
Technical specifications
Reference specifications describe the material. They do not replace the analytical results for a specific batch.
- Chemical name
- D-retro-inverso peptide derived from the FOXO4-p53 interaction domain
- Sequence
- Not available
- Molecular formula
- Not available
- Molecular weight
- Not available
- CAS number
- Not available
- Form
- Lyophilized powder
- Appearance
- White to off-white solid
- Purity specification
- Declared in the batch certificate
- Identity
- Declared in the batch certificate
- Solubility
- Soluble in sterile water and bacteriostatic water
- Storage
- −20 °C, protected from light
- Stability after reconstitution
- Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol
Batch documentation
Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.
Consult batch certificates How to read documentationLaboratory handling
- Reconstitution
- Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
- Storage
- Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
- Protective equipment
- Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Research references
- Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell · 2017 · PMID 28340339
- Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.
Naunyn Schmiedebergs Arch Pharmacol · 2026 · PMID 42024235
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Nat Commun · 2025 · PMID 40593617
- Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes.
Front Bioeng Biotechnol · 2021 · PMID 33996787
Frequently asked questions
How is FOXO4-DRI supplied?
FOXO4-DRI is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.
How is FOXO4-DRI stored in the laboratory?
Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.
