Melanocortins
Melanotan-2
Selecting Melanotan-2 requires preserving the full name and distinguishing it from Melanotan-1. The presentation indicates mass per vial; structure and bibliographic context are documented separately.
Your selected presentation
Availability to be confirmed · SKU MT2-10
For laboratory research only. Not for human or veterinary use.
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About this compound
Cyclization restricts the peptide's conformation and modifies its relative affinity for receptor subtypes. All of these are Gs protein-coupled receptors in cellular models.
Read the complete research referenceBatch documentation
Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.
Review documentation informationResearch context & mechanism
Cyclization restricts the peptide's conformation and modifies its relative affinity for receptor subtypes. All of these are Gs protein-coupled receptors in cellular models.
Technical specifications
Reference specifications describe the material. They do not replace the analytical results for a specific batch.
- Chemical name
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Molecular formula
- C50H69N15O9
- Molecular weight
- 1024.2 Da
- CAS number
- 121062-08-6
- Form
- Lyophilized powder
- Appearance
- White to off-white solid
- Purity specification
- Declared in the batch certificate
- Identity
- Declared in the batch certificate
- Solubility
- Soluble in sterile water and bacteriostatic water
- Storage
- −20 °C, protected from light
- Stability after reconstitution
- Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol
Batch documentation
Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.
Consult batch certificates How to read documentationLaboratory handling
- Reconstitution
- Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
- Storage
- Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
- Protective equipment
- Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Research references
- Discovery and development of novel melanogenic drugs. Melanotan-I and -II
Pharm Biotechnol · 1998 · PMID 9760697
- Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization
Peptides · 2006 · PMID 16412534
- Melanotan II User Experience: A Qualitative Study of Online Discussion Forums
Dermatology · 2021 · PMID 34464955
- Melanotan II: a possible cause of renal infarction: review of the literature and case report
CEN Case Rep · 2020 · PMID 31953620
- Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.
J Med Chem · 1989 · PMID 2555512
- A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice.
Rapid Commun Mass Spectrom · 2007 · PMID 17610239
Frequently asked questions
How is Melanotan-2 supplied?
Melanotan-2 is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.
How is Melanotan-2 stored in the laboratory?
Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.


