MOTS-c

Technical specifications

Reference specifications describe the material. They do not replace the analytical results for a specific batch.

Chemical name

Peptide derived from mitochondrial 12S rRNA

Sequence

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Molecular formula

Not available

Molecular weight

2174.6 Da

CAS number

1627580-64-6

Form

Lyophilized powder

Appearance

White to off-white solid

Purity specification

Declared in the batch certificate

Identity

Declared in the batch certificate

Solubility

Soluble in sterile water and bacteriostatic water

Storage

−20 °C, protected from light

Stability after reconstitution

Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol

Batch documentation

Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.

Laboratory handling

Reconstitution

Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.

Storage

Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.

Protective equipment

Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Research references

1. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

   Cell Metab · 2015 · PMID 25738459

2. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

   Nat Commun · 2021 · PMID 33473109

3. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases

   Int J Mol Sci · 2022 · PMID 36233287

4. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation

   Front Endocrinol (Lausanne) · 2023 · PMID 36761202

5. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

   Cell Metab · 2018 · PMID 29983246

6. Orally administered MOTS-c analogue ameliorates dextran sulfate sodium-induced colitis by inhibiting inflammation and apoptosis.

   Eur J Pharmacol · 2023 · PMID 36528071

Frequently asked questions