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Metabolic compounds

5-Amino-1MQ

5-Amino-1MQ is a small molecule, not a peptide. Selection requires checking the declared identity and chemical form; sharing a research category with peptides does not make their specifications equivalent.

ASCIENDE / AMQ-1010 mg
10 mg1 unit

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Available · SKU AMQ-10

$1,188MXN
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For laboratory research only. Not for human or veterinary use.

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About this compound

NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide. Its inhibition modulates nicotinamide availability in the dinucleotide salvage pathway in cellular models.

Read the complete research reference
Batch documentation

Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.

Review documentation information

Research context & mechanism

NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide. Its inhibition modulates nicotinamide availability in the dinucleotide salvage pathway in cellular models.

Technical specifications

Reference specifications describe the material. They do not replace the analytical results for a specific batch.

Chemical name
5-amino-1-methylquinolin-1-ium (iodide salt)
Sequence
Not available
Molecular formula
Not available
Molecular weight
Not available
CAS number
Not available
Form
Lyophilized powder
Appearance
White to pale yellow solid
Purity specification
Declared in the batch certificate
Identity
Declared in the batch certificate
Solubility
Soluble in sterile water
Storage
−20 °C, protected from light
Stability after reconstitution
Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol

Batch documentation

Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.

Consult batch certificates How to read documentation

Laboratory handling

Reconstitution
Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
Storage
Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
Protective equipment
Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Research references

  1. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

    Biochem Pharmacol · 2019 · PMID 30753815

  2. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

    Sci Rep · 2021 · PMID 33707534

  3. Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation

    Trends Pharmacol Sci · 2026 · PMID 42067476

  4. Mechanisms and inhibitors of nicotinamide N-methyltransferase

    RSC Med Chem · 2021 · PMID 34458733

  5. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

    Biochem Pharmacol · 2018 · PMID 29155147

  6. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

    Nature · 2014 · PMID 24717514

Frequently asked questions

How is 5-Amino-1MQ supplied?

5-Amino-1MQ is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.

How is 5-Amino-1MQ stored in the laboratory?

Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.

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