Metabolic compounds
Semaglutide
An analog name alone does not identify its presentation. For Semaglutide, match quantity, chemical identification and batch. GLP-1 references contextualize the molecule; they do not certify this commercial material.
Your selected presentation
Available · SKU SEMA-05
For laboratory research only. Not for human or veterinary use.
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About this compound
Replacing alanine with Aib at position 8 reduces degradation by dipeptidyl peptidase 4 in in vitro studies. Acylation promotes albumin binding and modifies the kinetics of receptor exposure in experimental models.
Read the complete research referenceBatch documentation
Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.
Review documentation informationResearch context & mechanism
Replacing alanine with Aib at position 8 reduces degradation by dipeptidyl peptidase 4 in in vitro studies. Acylation promotes albumin binding and modifies the kinetics of receptor exposure in experimental models.
Technical specifications
Reference specifications describe the material. They do not replace the analytical results for a specific batch.
- Chemical name
- N-epsilon-26-{2-[2-(2-{2-[2-(2-{(4S)-4-carboxy-4-[(17-carboxyheptadecanoyl)amino]butanoyl}amino)ethoxy]ethoxy}acetyl)amino]ethoxy}ethoxy-acetyl-[8-(2-amino-2-methylpropanoyl), 34-arginine]-GLP-1-(7-37) acid
- Sequence
- Not available
- Molecular formula
- C187H291N45O59
- Molecular weight
- 4113.58 Da
- CAS number
- 910463-68-2
- Form
- Lyophilized powder
- Appearance
- White to off-white solid
- Purity specification
- Declared in the batch certificate
- Identity
- Declared in the batch certificate
- Solubility
- Soluble in sterile water and bacteriostatic water
- Storage
- −20 °C, protected from light
- Stability after reconstitution
- Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol
Batch documentation
Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.
Consult batch certificates How to read documentationLaboratory handling
- Reconstitution
- Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
- Storage
- Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
- Protective equipment
- Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Research references
- Once-Weekly Semaglutide in Adults with Overweight or Obesity
N Engl J Med · 2021 · PMID 33567185
- Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
N Engl J Med · 2023 · PMID 37952131
- Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial
Lancet · 2018 · PMID 30122305
- The Discovery and Development of Liraglutide and Semaglutide
Front Endocrinol (Lausanne) · 2019 · PMID 31031702
- Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide
J Med Chem · 2015 · PMID 26308095
- Semaglutide lowers body weight in rodents via distributed neural pathways
JCI Insight · 2020 · PMID 32213703
Read more about this material
Frequently asked questions
How is Semaglutide supplied?
Semaglutide is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.
How is Semaglutide stored in the laboratory?
Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.



