Secretagogues and the GH axis
HGH
This presentation is expressed in IU, not mg. An activity unit cannot be converted to mass by simply changing the unit label; preserve the declared unit when comparing documents and recording material.
Your selected presentation
Available · SKU HGH-08
For laboratory research only. Not for human or veterinary use.
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About this compound
The growth hormone receptor lacks intrinsic catalytic activity and depends on its associated kinase, JAK2. Receptor dimerization and recruitment of the transcription factors STAT5A and STAT5B are described in cellular models. Preclinical literature also places the molecule in the hepatic IGF-1 pathway.
Read the complete research referenceBatch documentation
Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.
Review documentation informationResearch context & mechanism
The growth hormone receptor lacks intrinsic catalytic activity and depends on its associated kinase, JAK2. Receptor dimerization and recruitment of the transcription factors STAT5A and STAT5B are described in cellular models. Preclinical literature also places the molecule in the hepatic IGF-1 pathway.
Technical specifications
Reference specifications describe the material. They do not replace the analytical results for a specific batch.
- Chemical name
- Recombinant human growth hormone, mature chain of 191 amino acids (UniProt P01241, residues 27-217)
- Sequence
- FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
- Molecular formula
- C990H1528N262O300S7
- Molecular weight
- 22125 Da
- CAS number
- 12629-01-5
- Form
- Lyophilized powder
- Appearance
- White to off-white solid
- Purity specification
- Declared in the batch certificate
- Identity
- Declared in the batch certificate
- Solubility
- Soluble in sterile water and bacteriostatic water
- Storage
- −20 °C, protected from light
- Stability after reconstitution
- Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol
Batch documentation
Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.
Consult batch certificates How to read documentationLaboratory handling
- Reconstitution
- Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
- Storage
- Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
- Protective equipment
- Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Research references
- The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.
Front Endocrinol (Lausanne) · 2018 · PMID 29487568
- Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone.
Nature · 1979 · PMID 386136
Read more about this material
Frequently asked questions
How is HGH supplied?
HGH is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.
How is HGH stored in the laboratory?
Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.
Why is this product declared in IU rather than milligrams?
An IU is a unit of biological activity, not mass: it is defined by comparison with the WHO international standard in a potency assay, not by weighing. Converting an IU value to milligrams requires a potency specification determined for that particular material; without it, the conversion is unsupported and is not published on this page. This is why the presentation row is labeled ‘Activity’ rather than ‘Mass’.
How does it differ from HGH Fragment 176-191?
They are two different molecules, each with its own page. This product is the complete 191-amino-acid chain with its two disulfide bonds; HGH Fragment 176-191 reproduces only the final residues at the C-terminus and lacks the region associated with growth hormone receptor binding. They do not share a formula, mass or CAS number, and the literature for one does not apply to the other.
Where does numbering of the 191 amino acids in the sequence begin?
At the N-terminus of the mature chain, which is position 1. That chain corresponds to residues 27 through 217 of the UniProt P01241 precursor: the first 26 residues form the signal peptide and are not part of the molecule. Comparing this page with a source that numbers the precursor shifts every position by 26 residues.
