Melanocortins
Melanotan-1
Melanotan-1 and Melanotan-2 are different materials. The number in the name does not indicate a higher-concentration version: compare the declared structure and consult each entity’s record.
Your selected presentation
Availability to be confirmed · SKU MT1-10
For laboratory research only. Not for human or veterinary use.
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About this compound
MC1R is a Gs protein-coupled receptor present in melanocytes. Its activation modulates the cyclic AMP pathway and tyrosinase expression in cellular models.
Read the complete research referenceBatch documentation
Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.
Review documentation informationResearch context & mechanism
MC1R is a Gs protein-coupled receptor present in melanocytes. Its activation modulates the cyclic AMP pathway and tyrosinase expression in cellular models.
Technical specifications
Reference specifications describe the material. They do not replace the analytical results for a specific batch.
- Chemical name
- [Nle4, D-Phe7]-alpha-MSH
- Sequence
- Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- Molecular formula
- C78H111N21O19
- Molecular weight
- 1646.9 Da
- CAS number
- 75921-69-6
- Form
- Lyophilized powder
- Appearance
- White to off-white solid
- Purity specification
- Declared in the batch certificate
- Identity
- Declared in the batch certificate
- Solubility
- Soluble in sterile water and bacteriostatic water
- Storage
- −20 °C, protected from light
- Stability after reconstitution
- Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol
Batch documentation
Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.
Consult batch certificates How to read documentationLaboratory handling
- Reconstitution
- Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
- Storage
- Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
- Protective equipment
- Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.
Research references
- Afamelanotide for Erythropoietic Protoporphyria.
N Engl J Med · 2015 · PMID 26132941
- Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo: a randomized multicenter trial.
JAMA Dermatol · 2015 · PMID 25230094
- Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders.
Clin Pharmacokinet · 2017 · PMID 28063031
- Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review.
Int J Dermatol · 2017 · PMID 28266027
Frequently asked questions
How is Melanotan-1 supplied?
Melanotan-1 is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.
How is Melanotan-1 stored in the laboratory?
Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.


