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ASCIENDE

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Metabolic compounds

Semaglutide

An analog name alone does not identify its presentation. For Semaglutide, match quantity, chemical identification and batch. GLP-1 references contextualize the molecule; they do not certify this commercial material.

ASCIENDE / SEMA-055 mg
5 mg1 unit

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Availability to be confirmed · SKU SEMA-05

$2,100MXN
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For laboratory research only. Not for human or veterinary use.

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About this compound

Replacing alanine with Aib at position 8 reduces degradation by dipeptidyl peptidase 4 in in vitro studies. Acylation promotes albumin binding and modifies the kinetics of receptor exposure in experimental models.

Read the complete research reference
Batch documentation

Ask support which documents are available for the selected variant and batch. Catalog specifications do not establish an individual batch result.

Review documentation information

Research context & mechanism

Replacing alanine with Aib at position 8 reduces degradation by dipeptidyl peptidase 4 in in vitro studies. Acylation promotes albumin binding and modifies the kinetics of receptor exposure in experimental models.

Technical specifications

Reference specifications describe the material. They do not replace the analytical results for a specific batch.

Chemical name
N-epsilon-26-{2-[2-(2-{2-[2-(2-{(4S)-4-carboxy-4-[(17-carboxyheptadecanoyl)amino]butanoyl}amino)ethoxy]ethoxy}acetyl)amino]ethoxy}ethoxy-acetyl-[8-(2-amino-2-methylpropanoyl), 34-arginine]-GLP-1-(7-37) acid
Sequence
Not available
Molecular formula
C187H291N45O59
Molecular weight
4113.58 Da
CAS number
910463-68-2
Form
Lyophilized powder
Appearance
White to off-white solid
Purity specification
Declared in the batch certificate
Identity
Declared in the batch certificate
Solubility
Soluble in sterile water and bacteriostatic water
Storage
−20 °C, protected from light
Stability after reconstitution
Keep refrigerated at 2–8 °C and use within the period defined by the laboratory protocol

Batch documentation

Review documentation for the product and variant you are purchasing. A reference specification, a research publication and an individual batch certificate are different sources. Ask support which documents are available for your chosen variant and batch. No analytical result should be assumed from a catalog specification.

Consult batch certificates How to read documentation

Laboratory handling

Reconstitution
Laboratory procedure: allow the closed vial to reach room temperature, disinfect the septum and slowly transfer the diluent against the inner wall of the vial. Do not shake; gently swirl the vial until fully dissolved. Record the volume, diluent and date in the batch log.
Storage
Sealed vial of lyophilized material: store at −20 °C, protected from light and moisture. Avoid repeated freeze-thaw cycles of reconstituted material; aliquot when the experimental design permits.
Protective equipment
Handle in a clean work area with a lab coat, nitrile gloves and eye protection. Dispose of vials, tips and sharps according to the laboratory waste procedure.

Research references

  1. Once-Weekly Semaglutide in Adults with Overweight or Obesity

    N Engl J Med · 2021 · PMID 33567185

  2. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

    N Engl J Med · 2023 · PMID 37952131

  3. Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial

    Lancet · 2018 · PMID 30122305

  4. The Discovery and Development of Liraglutide and Semaglutide

    Front Endocrinol (Lausanne) · 2019 · PMID 31031702

  5. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide

    J Med Chem · 2015 · PMID 26308095

  6. Semaglutide lowers body weight in rodents via distributed neural pathways

    JCI Insight · 2020 · PMID 32213703

Frequently asked questions

How is Semaglutide supplied?

Semaglutide is supplied in a sealed vial containing the quantity indicated for the selected variant, with its batch identifier printed on the label.

How is Semaglutide stored in the laboratory?

Store the closed vial at −20 °C, protected from light and moisture. See the laboratory handling section of this page for the complete procedure.

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